I haven’t gotten around to posting anything here lately, this is my first post in almost 2 weeks. What have I been doing with myself lately? Oh, cooking, cleaning, going to work, paying bills, and thinking about life and death. I mentioned in a previous blog that I had a “direct-to-consumer” DNA evaluation done a few years ago on 23andme.com, and along with the genealogy information, 23 also gave you an assessment of your genetically-related health risks. (Since then, the US FDA has stopped them from providing health reports — 23andme still offers genealogy tests). My own results on 23 seemed fairly benign — one or two things that might eventually become an issue, but nothing all that terrible.
Recently, however, I learned that you can access your digital DNA results from 23andme and upload them onto a site called Promethese.com, and for $5 they will give you a very detailed list of how your “SNP pairings” stack up against the SNPedia.com “wiki” database of health-related genetic studies. This seemed like a good idea to me, since my health reports from 23andme were based on a pool of gene studies that appears to have last been updated in 2011 (many months before I sent in my saliva, in mid-2013; incidentally, that was only about 6 months before the FDA shut 23’s health service down). A lot of new knowledge about genes and health must have come out since them. So, I got my results from Promethease (it takes only a few minutes, actually) and have spent a lot of time pouring over them in the past few weeks. Bottom line . . . in great detail, they paint a much darker picture of my susceptibility to a wide variety of diseases than 23andme did.
In comparing some of the Promethease / SNPedia results with the 23 reports, it turns out that 23andme wasn’t always considering the full range of DNA studies available up through 2011, and in some instances, it misinterpreted them!!! For one condition involving eyesight » continue reading …

